PUBLICATIONS

Sabina Kanton#, Xiangling Meng#, Chunyang Dong#, Fikri Birey, Dong Wang, Noah A. Reis, Se-Jin Yoon, Ji-Il Kim, James P. McQueen, Noriaki Sakai, Seiji Nishino, John R. Huguenard, & Sergiu P. Pasca. Human neuromodulatory assembloids to study serotonin signaling in disease. bioRxiv (2026, # co-first).

Xiangling Meng, Noah Reis, Michael C Bassik, Sergiu P Pasca. CRISPR Screens in Human Neural Organoids and Assembloids. Nature Protocol (2025). https://doi.org/10.1038/s41596-025-01299-6.

Xiaoyu Chen, Fikri Birey, Min-Yin Li Omer Revah, Rebecca Levy, Mayuri Vijay Thete, Noah Reis, Konstantin Kaganovsky, Massimo Onesto, Noriaki Sakai, Zuzana Hudacova, Jin Hao, Xiangling Meng, Seiji Nishino, John Huguenard and Sergiu P. Pașca. Antisense oligonucleotide therapeutic approach for Timothy syndrome. Nature (2024)

Ji-il Kim, Yuki Miura, Min-Yin Li, Omer Revah, Sridhar Selvaraj, Fikri Birey, Xiangling Meng, Mayuri Vijay Thete, Sergey D Pavlov, Jimena Anderson, Anca M Pasca, Matthew H Porteus, John R Huguenard, Sergiu P Pasca. Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway. Neuron (2024). DOI: 10.1016/j.neuron.2024.09.020.

Xiangling Meng, David Yao, Kevin W Kelley, Noah Reis, Mayuri V Thete, Shravanti Kulkarni, Michael C Bassik, Sergiu P Pasca. Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment. Nature (2023). https://doi.org/10.1038/s41586-023-06564-w

Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P. Tirumala, Carlo Vetralla, Sameer S. Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J. Ferrie, Anel LaGrone, Ping Zhang, Jean J. Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tjian and Huda Y. Zoghbi. A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Genes Dev (2023). DOI: 10.1101/gad.350733.123

John V Pluvinage, Jerry Sun, Christel Claes, Ryan A Flynn, Michael S Haney, Tal Iram, Xiangling Meng, Rachel Lindemann, Nicholas M Riley, Emma Danhash, Jean Paul Chadarevian, Emma Tapp, David Gate, Sravani Kondapavulur, Inma Cobos, Sundari Chetty, Anca M Pașca, Sergiu P Pașca, Elizabeth Berry-Kravis, Carolyn R Bertozzi, Mathew Blurton-Jones, Tony Wyss-Coray. The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Science Translational Medicine (2021). https://www.science.org/doi/10.1126/scitranslmed.abg2919.

Xiangling Meng, Christopher M McGraw, Wei Wang, Junzhan Jing, Szu-Ying Yeh, Li Wang, Joanna Lopez, Amanda M Brown, Tao Lin, Wu Chen, Mingshan Xue, Roy V Sillitoe, Xiaolong Jiang, Huda Y Zoghbi. Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions. eLife 2019;8:e46773. https://elifesciences.org/articles/46773

Xiangling Meng, Wei Wang, Hui Lu, Ling-jie He, Wu Chen, Eugene Chao, Marta L. Fiorotto, Bin Tang, Jose A. Herrera, Michelle L. Seymour, Jeffrey L. Neul, Fred A. Pereira, Jianrong Tang, Mingshan Xue, Huda Y. Zoghbi. Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. eLife 2016;10.7554/eLife.14199. https://elifesciences.org/articles/14199.

Hui Lu, Ryan T. Ash, Lingjie He, Sara E. Kee, Wei Wang, Dinghui Yu, Shuang Hao, Xiangling Meng, Kerstin Ure, Aya Ito-Ishida, Bin Tang, Yaling Sun, Daoyun Ji, Jiangrong Tang, Benjamin R. Arenkiel, Stelios M. Smirnakis, and Huda Y. Zoghbi. Loss and gain of MeCP2 lead to similar hippocampal circuit abnormalities that are rescued by deep brain stimulation in a Rett syndrome mouse model. Neuron. https://www.cell.com/neuron/pdfExtended/S0896-6273(16)30403-2.